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Lipopolysaccharides, from E. coli O55:B5

Lipopolysaccharides, from E. coli O55:B5

Item no.	HY-D1056-100mg
Manufacturer	MedChem Express
Amount	100 mg
Quantity options	100 mg 10 mg 1 mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitor
Specific against	other
Citations	[1]Krukenberg KA, et al. Extracellular poly(ADP-ribose) is a pro-inflammatory signal for macrophages. Chem Biol. 2015 Apr 23;22(4):446-452.\|[2]Gayle DA, et al. Lipopolysaccharide (LPS)-induced dopamine cell loss in culture: roles of tumor necrosis factor-alpha, interleukin-1beta, and nitric oxide. Brain Res Dev Brain Res. 2002 Jan 31;133(1):27-35.\|[3]Xiao Z, et al. Ferrostatin-1 alleviates lipopolysaccharide-induced cardiac dysfunction. Bioengineered. 2021 Dec;12(2):9367-9376.\|[4]Huang S, et al. Disruption of the Na+/K+-ATPase-purinergic P2X7 receptor complex in microglia promotes stress-induced anxiety. Immunity. 2024 Mar 12;57(3):495-512.e11.\|[5]Guo D, et al. Synergistic rheumatoid arthritis therapy by interrupting the detrimental feedback loop to orchestrate hypoxia M1 macrophage polarization using an enzyme-catalyzed nanoplatform. Bioact Mater. 2024 Jul 23;41:221-238.\|[6]Yang J, et al. MicroRNA-106a Provides Negative Feedback Regulation in Lipopolysaccharide-Induced Inflammation by targeting TLR4. Int J Biol Sci. 2019 Aug 22;15(11):2308-2319.\|[7]Makrecka-Kuka M, et al. Inhibition of CPT2 exacerbates cardiac dysfunction and inflammation in experimental endotoxaemia. J Cell Mol Med. 2020 Oct;24(20):11903-11911.
Smiles	[Lipopolysaccharides, from E. coli O55:B5]
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	LPS
Shipping Condition	Room temperature
Available
Manufacturer - Type	Biochemical Assay Reagents
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	Toll-like Receptor (TLR)
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Product Description	Lipopolysaccharides, from E. coli O55:B5 (LPS, from Escherichia coli (O55:B5)) are endotoxins and TLR4 activators extracted from Escherichia coli (E. coli O55:B5) and are classified as S (smooth) type LPS. Lipopolysaccharides, from E. coli O55:B5 possess the typical three-part structure: O-antigen, core oligosaccharide, and lipid A. Lipopolysaccharides, from E. coli O55:B5 activate TLR-4 in immune cells, exhibit high pyrogenicity, and demonstrate dose and serotype specificity. Lipopolysaccharides, from E. coli O55:B5 can be used to induce cellular inflammation and establish animal models related to inflammation[1][2][3][4][5][6][7].It is recommended to prepare a stock solution of ≥2 mg/mL. Due to the adsorption characteristics of LPS, low adsorption centrifuge tubes should be used for aliquoting and storage.
Manufacturer - Research Area	Inflammation/Immunology; Cancer
Solubility	DMSO: 50 mg/mL (ultrasonic; warming; heat to 60°C)\|H2O: 5 mg/mL (ultrasonic)
Manufacturer - Pathway	Immunology/Inflammation
Isoform	TLR4
Clinical information	Phase 4

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HY-D1056-100mg-safety-datasheet.pdf