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Peimine

Peimine

Item no.	HY-N0212-100mg
Manufacturer	MedChem Express
CASRN	23496-41-5
Amount	100 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 1 mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitor
Specific against	other
Purity	99.43
Citations	[6]Yi PF, et al. Peimine impairs pro-inflammatory cytokine secretion through the inhibition of the activation of NF-κB and MAPK in LPS-induced RAW264.7 macrophages. Immunopharmacol Immunotoxicol. 2013 Oct;35(5):567-72. \|[7]Xu J, et al. Peimine, a main active ingredient of Fritillaria, exhibits anti-inflammatory and pain suppression properties at the cellular level. Fitoterapia. 2016 Jun;111:1-6. \|[1]Yi PF, et al. Peimine impairs pro-inflammatory cytokine secretion through the inhibition of the activation of NF-κB and MAPK in LPS-induced RAW264.7 macrophages. Immunopharmacol Immunotoxicol. 2013 Oct;35(5):567-72.\|[2]Chen K, Lv ZT, Zhou CH, et al. Peimine suppresses interleukin‑1β‑induced inflammation via MAPK downregulation in chondrocytes. Int J Mol Med. 2019;43(5):2241-2251. \|[3]Tan H, et al. Peimine inhibits the growth and motility of prostate cancer cells and induces apoptosis by disruption of intracellular calcium homeostasis through Ca2+ /CaMKII/JNK pathway. J Cell Biochem. 2020 Jan;121(1):81-92. \|[4]Liu C, et al. Synergistic anti-inflammatory effects of peimine, peiminine, and forsythoside a combination on LPS-induced acute lung injury by inhibition of the IL-17-NF-κB/MAPK pathway activation. J Ethnopharmacol. 2022 Sep 15;295:115343. \|[5]Chen LH, et al. Sex dependent pharmacokinetics, tissue distribution and excretion of peimine and peiminine in rats assessed by liquid chromatography-tandem mass spectrometry. J Ethnopharmacol. 2013 Jan 9;145(1):77-84.
Smiles	[H][C@]12[C@]3([H])C[C@H](O)[C@@]4([H])C[C@@H](O)CC[C@]4(C)[C@@]3([H])C[C@]([H])1[C@]5([H])CN6C[C@@H](C)CC[C@]([H])6[C@@](C)(O)[C@]([H])5CC2
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Verticine,Dihydroisoimperialine
Shipping Condition	Room temperature
Available
Manufacturer - Type	Natural Products
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	Apoptosis; Interleukin Related; NF-κB; p38 MAPK; TNF Receptor
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, protect from light)
Molecular Weight	431.65
Product Description	Peimine (Verticine; Dihydroisoimperialine) is an orally active natural product. Peimine has anti-inflammatory, analgesic and cough relieving effects. Peimine can be used in cancer and inflammation related research[1][2][3][4][5][6][7].
Manufacturer - Research Area	Cancer; Inflammation/Immunology
Solubility	DMSO: 50 mg/mL (ultrasonic)
Manufacturer - Pathway	Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; NF-κB
Isoform	IL-1; IL-10; IL-6; NF-κB; p38 MAPK
Clinical information	No Development Reported

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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HY-N0212-100mg-safety-datasheet.pdf