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Cardamonin

Cardamonin

Item no.	HY-N0279-5mg
Manufacturer	MedChem Express
CASRN	18956-16-6
Amount	5 mg
Quantity options	10 mM/1 mL 10 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.38
Citations	[1]Javaria Nawaz, et al. Cardamonin: A new player to fight cancer via multiple cancer signaling pathways. Life Sci. 2020 Jun 1;250:117591.\|[2]Kai Wang, et al. Cardamonin, a natural flavone, alleviates inflammatory bowel disease by the inhibition of NLRP3 inflammasome activation via an AhR/Nrf2/NQO1 pathway. Biochem Pharmacol. 2018 Sep;155:494-509.\|[3]Zheng Wang, et al. Cardamonin exerts anti-gastric cancer activity via inhibiting LncRNA-PVT1-STAT3 axis. Biosci Rep. 2019 May 17;39(5):BSR20190357.\|[4]Wang Qi, et al. Cardamonin protects against doxorubicin-induced cardiotoxicity in mice by restraining oxidative stress and inflammation associated with Nrf2 signaling. Biomed Pharmacother. 2020 Feb;122:109547.
Smiles	O=C(C1=C(OC)C=C(O)C=C1O)/C=C/C2=CC=CC=C2
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Cardamomin,Alpinetin chalcone
Shipping Condition	Room temperature
Available
Manufacturer - Type	Natural Products
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	Apoptosis; Bcl-2 Family; NF-κB; STAT; Wnt; β-catenin
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	270.28
Product Description	Cardamonin can be found from cardamom, and can target various signaling molecules, transcriptional factors, cytokines and enzymes. Cardamonin can inhibit mTOR, NF-κB, Akt, STAT3, Wnt/β-catenin and COX-2. Cardamonin shows anticancer, anti-inflammatory, antimicrobial and antidiabetic activities[1][2].
Manufacturer - Research Area	Cancer; Metabolic Disease; Inflammation/Immunology; Cardiovascular Disease
Solubility	DMSO: 125 mg/mL (ultrasonic)
Manufacturer - Pathway	Apoptosis; JAK/STAT Signaling; NF-κB; Stem Cell/Wnt
Clinical information	No Development Reported

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HY-N0279-5mg-safety-datasheet.pdf