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Mangiferin

Mangiferin

Manufacturer	MedChem Express
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Amount	5mg
Item no.	HY-N0290-5mg
CASRN	4773-96-0
Available
Product Description	Mangiferin is a Nrf2 activator. Mangiferin suppresses nuclear translocation of the NF-κB subunits p65 and p50. Mangiferin exhibits antioxidant, antidiabetic, antihyperuricemic, antiviral, anticancer and antiinflammatory activities.
StorageTemperature	Powder -20°C 3 years, 4°C 2 years; In solvent -80°C 6 months, -20°C 1 month
Applications	Cancer-programmed cell death
Formula	C19H18O11
References	[1].Zhang BP, et al. Mangiferin activates Nrf2-antioxidant response element signaling without reducing the sensitivity to etoposide of human myeloid leukemia cells in vitro. Acta Pharmacol Sin. 2014 Feb; 35(2):257-66. \| [2].Dilshara MG, et al. Mangiferin inhibits tumor necrosis factor-α-induced matrix metalloproteinase-9 expression and cellular invasion by suppressing nuclear factor-κB activity. BMB Rep. 2015 Oct; 48(10):559-64.
MolecularWeight	422.34
Research Area	Cancer
Solubility	DMSO : 31.25 mg/mL (73.99 mM; ultrasonic and warming and heat to 80°C)
Target	NF-κB; Keap1-Nrf2; Apoptosis
Isoform	p65; p50; Nrf2
Pathway	NF-κB; Apoptosis

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Amount: 5mg

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Delivery expected until 10/12/2023