« Back
Home /
Sennoside B

Sennoside B

Item no.	HY-N0366-5mg
Manufacturer	MedChem Express
CASRN	128-57-4
Amount	5 mg
Quantity options	10 mM/1 mL 10 mg 20 mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.23
Citations	[1]Hwang IY, et al. Gastroprotective Activities of Sennoside A and Sennoside B via the Up-Regulation of Prostaglandin E2 and the Inhibition of H(+)/K(+)-ATPase. Biomol Ther (Seoul). 2015 Sep;23(5):458-64.\|[2]Chen YC, et al. Sennoside B inhibits PDGF receptor signaling and cell proliferation induced by PDGF-BB in human osteosarcoma cells. Life Sci. 2009 Jun 19;84(25-26):915-22.
Smiles	O[C@@H]1[C@@H](O)[C@H](OC2=C(C(C(C(O)=CC(C(O)=O)=C3)=C3[C@]4([C@@]5(C(C=CC=C6O[C@H]7[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O7)=C6C(C8=C5C=C(C(O)=O)C=C8O)=O)[H])[H])=O)C4=CC=C2)O[C@H](CO)[C@H]1O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	128-57-4
Shipping Condition	Room temperature
Available
Manufacturer - Type	Natural Products
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Targets	PDGFR
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture and light)
Molecular Weight	862.74
Product Description	Sennoside B is a potent and orally active platelet-derived growth factor (PDGF) inhibitor. Sennoside B inhibits cell proliferation and the expression of phosphorylation of PDGFR-β, STAT-5, AKT and ERK induced by PDGF-BB. Sennoside B shows gastroprotective activities. Sennoside B has the potential for the research of gastritis[1][2].
Manufacturer - Research Area	Inflammation/Immunology
Solubility	DMSO: 100 mg/mL (ultrasonic)
Manufacturer - Pathway	Protein Tyrosine Kinase/RTK
Clinical information	No Development Reported

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

HY-N0366-5mg-safety-datasheet.pdf