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Cucurbitacin B

Cucurbitacin B

Item no.	HY-N0416-1mg
Manufacturer	MedChem Express
CASRN	6199-67-3
Amount	1 mg
Quantity options	10mM/1mL 10 mg 1 mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.92
Formula	C32H46O8
Citations	[1]Shang Y, et al. Cucurbitacin-B inhibits neuroblastoma cell proliferation through up-regulation of PTEN. Eur Rev Med Pharmacol Sci. 2014;18(21):3297-303. [2]Zhang M, et al. Cucurbitacin B inhibits proliferation and induces apoptosis via STAT3 pathway inhibition in A549 lung cancer cells. Mol Med Rep. 2014 Dec;10(6):2905-11. [3]Gupta P, et al. Inhibition of Integrin-HER2 signaling by Cucurbitacin B leads to in vitro and in vivo breast tumor growth suppression. Oncotarget. 2014 Apr 15;5(7):1812-28. [4]Guo J, et al. Cucurbitacin B induced ATM-mediated DNA damage causes G2/M cell cycle arrest in a ROS-dependent manner. PLoS One. 2014 Feb 4;9(2):e88140. [5]Dai S, , et al. Cucurbitacin B: A review of its pharmacology, toxicity, and pharmacokinetics. Pharmacol Res. 2023;187:106587. [6]Klungsaeng, et al. Targeted Modulation of FAK/PI3K/PDK1/AKT and FAK/p53 Pathways by Cucurbitacin B for the Antiproliferation Effect Against Human Cholangiocarcinoma Cells. Am J Chin Med. 2020;48(6):1475-1489. [7]Lin Y, et al. Cucurbitacin B Exerts Antiaging Effects in Yeast by Regulating Autophagy and Oxidative Stress. Oxid Med Cell Longev. 2019;2019:4517091. [8]Aljohani OS. Phytochemical evaluation of Cucumis prophetarum: protective effects against carrageenan-induced prostatitis in rats. Drug Chem Toxicol. 2022;45(4):1461-1469. [9]Liu Z, Kumar M, Kabra A. Cucurbitacin B exerts neuroprotection in a murine Alzheimer's disease model by modulating oxidative stress, inflammation, and neurotransmitter levels. Front Biosci (Landmark Ed). 2022;27(2):71.
Smiles	O[C@H](C1)[C@@]([C@@](C)(O)C(/C=C/C(OC(C)=O)(C)C)=O)([H])[C@](C2)(C)[C@]1(C)[C@]3([H])CC=C4C(C)(C)C([C@@H](O)C[C@@]4([H])[C@]3(C)C2=O)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Shipping Condition	Room temperature
Available
Manufacturer - Type	Natural Products
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Apoptosis; Autophagy; COX; Endogenous Metabolite; HIF/HIF Prolyl-Hydroxylase; Integrin; ROS Kinase
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	558.70
Product Description	Cucurbitacin B belongs to a class of highly oxidized tetracyclic triterpenoids and is oral active. Cucurbitacin B inhibits tumor cell growth, migration and invasion and cycle arrest, but induces cell apoptosis. Cucurbitacin B has potent anti-inflammatory, antioxidant, antiviral, hypoglycemic, hepatoprotective, neuroprotective activity[1][2][3][4][5].
Manufacturer - Research Area	Cancer; Inflammation/Immunology; Neurological Disease; Others
Solubility	DMSO : ≥ 100 mg/mL\|H2O : < 0.1 mg/mL
Manufacturer - Pathway	Apoptosis; Autophagy; Cytoskeleton; Immunology/Inflammation; Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK
Clinical information	No Development Reported

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HY-N0416-1mg-safety-datasheet.pdf