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Chicoric acid

Chicoric acid

Manufacturer	MedChem Express
Category	Inhibitors
Type	Inhibitors
Specific against	other
Amount	10mM*1mL
Item no.	HY-N0457-10mM*1mL
CASRN	6537-80-0
Available
Product Description	Chicoric acid (Cichoric acid), an orally active dicaffeyltartaric acid, induces reactive oxygen species (ROS) generation. Chicoric acid inhibits cell viability and induces mitochondria-dependent apoptosis in 3T3-L1 preadipocytes through ROS-mediated PI3K/Akt and MAPK signaling pathways. Chicoric acid increases glucose uptake, improves insulin resistance, and attenuates glucosamine-induced inflammation. Chicoric acid has antidiabetic properties and antioxidant, anti-inflammatory effects.
StorageTemperature	Powder -20°C 3 years, 4°C 2 years; In solvent -80°C 6 months, -20°C 1 month
Formula	C22H18O12
References	[1].Haifang Xiao, et al. Chicoric acid induces apoptosis in 3T3-L1 preadipocytes through ROS-mediated PI3K/Akt and MAPK signaling pathways. J Agric Food Chem. 2013 Feb 20; 61(7):1509-20. \| [2].Di Zhu, et al. Cichoric Acid Reverses Insulin Resistance and Suppresses Inflammatory Responses in the Glucosamine-Induced HepG2 Cells. J Agric Food Chem. 2015 Dec 30; 63(51):10903-13. \| [3].Di Zhu, et al. Cichoric acid improved hyperglycaemia and restored muscle injury via activating antioxidant response in MLD-STZ-induced diabetic mice. Food Chem Toxicol. 2017 Sep; 107(Pt A):138-149.
MolecularWeight	474.37
Research Area	Metabolic Disease; Inflammation/Immunology
Solubility	H2O : 100 mg/mL (210.81 mM; Need ultrasonic) \| DMSO : 1 mg/mL (2.11 mM; Need ultrasonic)
Target	Reactive Oxygen Species; Apoptosis
Pathway	Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Apoptosis

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Amount: 10mM*1mL

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Delivery expected until 4/13/2023

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