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Rhapontin

Rhapontin

Item no.	HY-N0671-5mg
Manufacturer	MedChem Express
CASRN	155-58-8
Amount	5 mg
Quantity options	10 mM/1 mL 10 mg 1 mg 20 mg 25 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.73
Citations	[1]Wei W, et al. Rhapontin ameliorates colonic epithelial dysfunction in experimental colitis through SIRT1 signaling. Int Immunopharmacol. 2017 Jan;42:185-194.\|[2]Tao L, et al. Protective role of rhapontin in experimental pulmonary fibrosis in vitro and in vivo. Int Immunopharmacol. 2017 Jun;47:38-46.\|[3]Hibasami H, et al. Induction of apoptosis by rhapontin having stilbene moiety, a component of rhubarb (<i>Rheum officinale Baillon</i>) in human stomach cancer KATO III cells. Oncol Rep. 2007 Aug;18(2):347-51.
Smiles	O[C@H]([C@@H](O)[C@@H]1O)[C@@H](O[C@@H]1CO)OC2=CC(/C=C/C3=CC(O)=C(OC)C=C3)=CC(O)=C2
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Rhaponiticin
Shipping Condition	Room temperature
Available
Manufacturer - Type	Natural Products
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Apoptosis
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, protect from light)
Molecular Weight	420.41
Product Description	Rhapontin (Rhaponiticin) is an orally aactive SIRT1 agonist and AMPK activator with anti-inflammatory and anti-fibrotic activities. Rhapontin inhibits NLRP3 inflammasome activation by activating SIRT1 and inhibits TGF-β/Smad signaling via the AMPK pathway. Rhapontin reduces intestinal and lung inflammation, inhibits fibroblast differentiation and extracellular matrix deposition, and enhances tight junction protein expression to repair epithelial barriers. Rhapontin can be used in the study of inflammatory bowel diseases (such as ulcerative colitis) and pulmonary fibrosis[1][2][3].
Manufacturer - Research Area	Cancer; Metabolic Disease; Inflammation/Immunology; Cardiovascular Disease
Solubility	DMSO: 250 mg/mL (ultrasonic)
Manufacturer - Pathway	Apoptosis
Clinical information	No Development Reported

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HY-N0671-5mg-safety-datasheet.pdf