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Demethylsuberosin

Demethylsuberosin

Item no.	HY-N2488-5mg
Manufacturer	MedChem Express
CASRN	21422-04-8
Amount	5 mg
Quantity options	10 mM/1 mL 10 mg 1 mg 20 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.71
Citations	[2]Yang X, et al. Angelica decursiva exerts antihypertensive activity by inhibiting L-type calcium channel. J Ethnopharmacol. 2023 Sep 15;313:116527.\|[3]Kang SY, et al. Neuroprotective coumarins from the root of Angelica gigas: structure-activity relationships. Arch Pharm Res. 2007 Nov;30(11):1368-73. \|[1]Yongfen Ma, et al. Anti-inflammatory Activities of Coumarins Isolated from Angelica gigas Nakai on LPS-stimulated RAW 264.7 Cells. J Food Sci Nutr Vol 14, p 179～187 (2009).
Smiles	O=C1C=CC2=CC(C/C=C(C)\C)=C(O)C=C2O1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	7-Demethylsuberosin
Shipping Condition	Room temperature
Available
Manufacturer - Type	Natural Products
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	Calcium Channel; NO Synthase
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	230.26
Product Description	Demethylsuberosin (7-Demethylsuberosin) is a coumarin compound found in Angelica gigas Nakai. Demethylsuberosin exerts antihypertensive effects by inhibiting the L-type CaV1.2 channel. Demethylsuberosin has antioxidant and anti-inflammatory activities. Demethylsuberosin also exhibits neuroprotective activities against glutamate-induced toxicity in primary cultured rat cortical cells[1][2][3].
Manufacturer - Research Area	Inflammation/Immunology; Neurological Disease; Cardiovascular Disease
Solubility	DMSO: 250 mg/mL (ultrasonic)
Manufacturer - Pathway	Immunology/Inflammation; Membrane Transporter/Ion Channel; Neuronal Signaling
Clinical information	No Development Reported

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HY-N2488-5mg-safety-datasheet.pdf