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Catalpalactone

Catalpalactone

Item no.	HY-N3548
Manufacturer	MedChem Express
CASRN	1585-68-8
Amount	1 ea
Quantity options	1 ea 1 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Formula	C15H14O4
Citations	[1]Kim HY, et al. Anti-Inflammatory Effects of Catalpalactone Isolated from Catalpa ovata in LPS-Induced RAW264.7 Cells. Molecules. 2019 Mar 29;24(7):1236. [2]Huang HS, et al. Effects of catalpalactone on dopamine biosynthesis and L-DOPA-induced cytotoxicity in PC12 cells. Environ Toxicol Pharmacol. 2008 Jul;26(1):86-91.
Smiles	O=C1OC(C2=CCC(C)(C)OC2=O)C3=C1C=CC=C3
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Shipping condition	Room temperature
Available
Manufacturer - Type	Natural Products
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	NF-κB
Shipping Temperature	Room Temperature
Molecular Weight	258.27
Product Description	Catalpalactone has anti-inflammatory effect. Catalpalactone inhibits LPS-induced NO production and iNOS expression in RAW264.7 cells, and also inhibits IRF3, NF-κB, and IFN-β/STAT-1 activation. Catalpalactone also inhibits dopamine biosynthesis by reducing tyrosine hydroxylase (TH) and aromatic-l-amino acid decarboxylase (AADC) activities[1][2].
Manufacturer - Research Area	Inflammation/Immunology
Solubility	10 mM in DMSO
Manufacturer - Pathway	NF-κB
Clinical information	No Development Reported

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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