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Cyclopiazonic acid

Cyclopiazonic acid

Item no.	HY-N6771-10mg
Manufacturer	MedChem Express
CASRN	18172-33-3
Amount	10 mg
Quantity options	10 mM/1 mL 10 mg 1 mg 5 mg
Category	Cardiovascular Research Ischemia & Reperfusion Injury Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.86
Citations	[1]Bonyadi F, et al. Cyclopiazonic acid induced p53-dependent apoptosis in the testis of mice: Another male related risk factor of infertility. Environ Toxicol. 2021 May;36(5):903-913. \|[2]Selli C, et al. Cyclopiazonic acid alters serotonin-induced responses in rat thoracic aorta. Vascul Pharmacol. 2014 May-Jun;61(2-3):43-8. \|[3]Chen Q, et al. Inhibitory Effects of Cyclopiazonic Acid on the Pacemaker Current in Sinoatrial Nodal Cells. Neuroscience. 2020 May 1;433:230-240. \|[4]Cui R, et al. Cyclopiazonic acid, an inhibitor of calcium-dependent ATPases with antiviral activity against human respiratory syncytial virus. Antiviral Res. 2016 Aug;132:38-45. \|[5] Kuilman-Wahls ME, et al. Cyclopiazonic acid inhibits mutagenic action of aflatoxin B(1). Environ Toxicol Pharmacol. 2002 Jul;11(3-4):207-12.
Smiles	O=C1C(C(C)=O)=C(O)[C@@]([C@]23[H])([H])N1C(C)(C)[C@]2([H])CC4=CC=CC5=C4C3=CN5
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	18172-33-3
Shipping Condition	Room temperature
Available
Manufacturer - Type	Natural Products
Manufacturer - Targets	5-HT Receptor; Apoptosis; Calcium Channel; MDM-2/p53; RSV
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	336.38
Product Description	Cyclopiazonic acid is an endoplasmic reticulum calcium ATPase (ECAs) inhibitor and human respiratory syncytial virus (RSV) inhibitor (EC50 value of 4.13 μ M), which can reduce the antagonistic effect of 5-HT receptors in rat thoracic aorta, induce p53 dependent cell apoptosis and reproductive toxicity in mouse testes, and inhibit the biological activation of aflatoxin B[1][4][5].
Manufacturer - Research Area	Infection
Solubility	DMSO: 100 mg/mL (ultrasonic)
Manufacturer - Pathway	Anti-infection; Apoptosis; GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling
Clinical information	No Development Reported

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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HY-N6771-10mg-safety-datasheet.pdf