Actein

Item no.	HY-N6872-1mg
Manufacturer	MedChem Express
CASRN	18642-44-9
Amount	1 mg
Quantity options	1 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.58
Citations	[1]Yang ZC, et al. Actein enhances TRAIL effects on suppressing gastric cancer progression by activating p53/Caspase-3 signaling. Biochem Biophys Res Commun. 2018 Mar 18;497(4):1177-1183.\|[2]Ji L, et al. Actein induces autophagy and apoptosis in human bladder cancer by potentiating ROS/JNK and inhibiting AKT pathways. Oncotarget. 2017 Nov 1;8(68):112498-112515.\|[3]Einbond LS, et al. Actein induces calcium release in human breast cancer cells. Fitoterapia. 2013 Dec;91:28-38.
Smiles	C[C@]12[C@@]3([H])[C@@]4(C[C@@H](OC(C)=O)[C@@]1([C@]5([H])[C@](O[C@]6([C@H]7[C@]([C@@H](O)O6)(C)O7)C[C@H]5C)([H])C2)C)[C@@]8([C@@](C(C)([C@@H](O[C@@]9([H])[C@@H]([C@H]([C@H](O)CO9)O)O)CC8)C)([H])CC3)C4
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Shipping Condition	Room temperature
Available
Manufacturer - Type	Natural Products
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Targets	Akt; Apoptosis; Autophagy; JNK; Reactive Oxygen Species (ROS)
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, protect from light)
Molecular Weight	676.83
Product Description	Actein, a triterpene glycoside, shows an inhibitory effect on cancer cells, which is isolated from the rhizomes of Cimicifuga foetida. Actein suppresses cell proliferation, induces autophagy and apoptosis through promoting ROS/JNK activation, and blunting AKT pathway in bladder cancer. Actein has little toxicity in vivo[1][2][3].
Manufacturer - Research Area	Cancer
Solubility	DMSO: 100 mg/mL (ultrasonic)
Manufacturer - Pathway	Apoptosis; Autophagy; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR
Clinical information	Phase 4

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HY-N6872-1mg-safety-datasheet.pdf