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Jasplakinolide

Jasplakinolide

Item no.	HY-P0027-100ug
Manufacturer	MedChem Express
CASRN	102396-24-7
Amount	100 ug
Quantity options	100 ug 50 ug
Category	Oncology By Cell Type Sarcoma Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.50
Citations	[1]Bubb MR, et al. Jasplakinolide, a cytotoxic natural product, induces actin polymerization and competitively inhibits the binding of phalloidin to F-actin. J Biol Chem. 1994 May 27;269(21):14869-71.\|[2]Holzinger A, et al. Jasplakinolide: an actin-specific reagent that promotes actin polymerization. Methods Mol Biol. 2009;586:71-87.
Smiles	BrC1=C(C2=CC=CC=C2N1)C[C@@H](N(C([C@@H](NC([C@H](C/C(C)=C/[C@@H]3C)C)=O)C)=O)C)C(N[C@](C(C=C4)=CC=C4O)([H])CC(O[C@H](C3)C)=O)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	102396-24-7
Similar products	102396-24-7
Shipping Condition	Cool pack
Available
Manufacturer - Type	Natural Products
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	Arp2/3 Complex; Fungal
Shipping Temperature	Blue Ice
Storage Conditions	-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Molecular Weight	709.67
Product Description	Jasplakinolide is a potent actin polymerization inducer and stabilizes pre-existing actin filaments. Jasplakinolide binds to F-actin competitively with phalloidin with a Kd of 15 nM. Jasplakinolide, a naturally occurring cyclic peptide from the marine sponge, has both fungicidal and anti-cancer activity[1][2].
Manufacturer - Research Area	Cancer; Infection
Solubility	DMSO : ≥ 2mg/mL
Manufacturer - Pathway	Anti-infection; Cytoskeleton
Clinical information	No Development Reported

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