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RO27-3225 (TFA)

RO27-3225 (TFA)

Item no.	HY-P2242A-10mM
Manufacturer	MedChem Express
Amount	10 mM/1 mL
Quantity options	10 mM/1 mL 10 mg 50 mg 5 mg
Category	Peptides & Proteins Peptides
Type	Peptides
Specific against	other
Purity	99.77
Citations	[1]Giuliani D, et al. Selective melanocortin MC4 receptor agonists reverse haemorrhagic shock and prevent multiple organ damage. Br J Pharmacol. 2007 Mar;150(5):595-603.\|[2]Zhang Y, et al. Effects of RO27-3225 on neurogenesis, PDGFRβ+ cells and neuroinflammation after cerebral infarction. Int Immunopharmacol. 2020 Feb 11;81:106281.\|[3]Benoit SC, et al. A novel selective melanocortin-4 receptor agonist reduces food intake in rats and mice without producing aversive consequences. J Neurosci. 2000 May 1;20(9):3442-8.
Smiles	CCCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N(CC(N)=O)C)=O)CC1=CNC2=C1C=CC=C2)=O)CCCNC(N)=N)=O)CC3=CC=CC=C3)=O)CC4=CN=CN4)=O.O=C(O)C(F)(F)F
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Shipping Condition	Cool pack
Available
Manufacturer - Type	Peptides
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	Melanocortin Receptor
Shipping Temperature	Blue Ice
Storage Conditions	-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)
Molecular Weight	898.93
Product Description	RO27-3225 TFA is potent and selective melanocortin 4 receptor (MC4R) agonist with an EC50 of 1 nM and 8 nM for MC4R and MC1R, respectively. RO27-3225 TFA shows ~30-fold selectivity for MC4R over MC3R. RO27-3225 TFA has neuroprotective and anti-inflammatory effects[1][2][3].
Manufacturer - Research Area	Inflammation/Immunology; Neurological Disease
Solubility	DMSO: 100 mg/mL (ultrasonic)\|H2O: 100 mg/mL (ultrasonic)
Manufacturer - Pathway	GPCR/G Protein; Neuronal Signaling
Isoform	MC4R
Clinical information	No Development Reported

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HY-P2242A-10mM-safety-datasheet.pdf