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IL-1R1, Rat (HEK293, His)

IL-1R1, Rat (HEK293, His)

Item no.	HY-P74822-50ug
Manufacturer	MedChem Express
Amount	50 ug
Quantity options	100 ug 10 ug 2 ug 50 ug
Category	Peptides & Proteins Recombinant Proteins
Type	Proteins Recombinant
Specific against	other
Purity	98.0
Sequence	LETDKCTEYP NEVISFSSVN EIDIRSCPLT PNEMHGGTII WYKNDSKTPI SADKDSRIHQ QNEHLWFVPA KMEDSGYYYC IMRNSTYCLK TKITMSVLEN DPGLCYNTQA SFIQRLHVAG DGSLVCPYLD FFKDENNELP KVQWYKNCKP LPLDDGNFFG FKNKLMVMNV AEEHRGNYTC RTSYTYQGKQ YPVTRVITFI TIDDSKRDRP VIMSPRNETM EADPGSTIQL IC
Citations	[1]Diana Boraschi, et al. The family of the interleukin-1 receptors. Immunol Rev. 2018 Jan;281(1):197-235.\|[2]Léa Chaskiel, et al. Interleukin-1 reduces food intake and body weight in rat by acting in the arcuate hypothalamus. Brain Behav Immun. 2019 Oct;81:560-573.\|[3]Naoe Kaneko, et al. The role of interleukin-1 in general pathology. Inflamm Regen. 2019 Jun 6;39:15.\|[4]Xiang Chu, et al. Coupling Between Interleukin-1R1 and Necrosome Complex Involves in Hemin-Induced Neuronal Necroptosis After Intracranial Hemorrhage. Stroke. 2018 Oct;49(10):2473-2482.\|[5]Siri Tahtinen, et al. IL-1 and IL-1ra are key regulators of the inflammatory response to RNA vaccines. Nat Immunol. 2022 Apr;23(4):532-542.
Smiles	LETDKCTEYP NEVISFSSVN EIDIRSCPLT PNEMHGGTII WYKNDSKTPI SADKDSRIHQ QNEHLWFVPA KMEDSGYYYC IMRNSTYCLK TKITMSVLEN DPGLCYNTQA SFIQRLHVAG DGSLVCPYLD FFKDENNELP KVQWYKNCKP LPLDDGNFFG FKNKLMVMNV AEEHRGNYTC RTSYTYQGKQ YPVTRVITFI TIDDSKRDRP VIMSPRNETM EADPGSTIQL ICNVTGQFTD LVYWKWNGSE IEWDDPILAE DYQFLEHPSA KRKYTLITTL NVSEVKSQFY RYPFICFVKN THILETAHVR LVYPVPDFK
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	IL-1R1 Protein,Rat (HEK293,His),Rat,HEK293
Shipping Condition	Cool pack
Available
Manufacturer - Type	Recombinant Proteins
Shipping Temperature	Blue Ice
Storage Conditions	Stored at -20°C for 2 years
Molecular Weight	52-75 kDa
Product Description	IL-1R1 (CD121a) belongs to IL-1 receptor, and binds to IL-1α, IL-1β, IL-1Ra and IL-38 with comparable affinities (Kd: 0.1-1 nM). IL-1R1 regulates the transcription of multiple proinflammatory cytokines and mediates immune and inflammatory responses, including the activation of NF-κB, MAPK pathways [1]. IL-1R1 Protein, Rat (HEK293, His) is a recombinant rat extracellular region of IL-1R1 (M1-K352) with a C terminal His tag, which is produced in HEK293 cells.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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