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2-Ketoglutaric acid

2-Ketoglutaric acid

Item no.	HY-W013636-500mg
Manufacturer	MedChem Express
CASRN	328-50-7
Amount	500 mg
Quantity options	10 mMx1 mL 1 g 500 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.90
Citations	[1]Huergo LF, et al. The Emergence of 2-Oxoglutarate as a Master Regulator Metabolite. Microbiol Mol Biol Rev. 2015 Dec;79(4):419-35.\|[2]Gou L, et al. The effect of alpha-ketoglutaric acid on tyrosinase activity and conformation: Kinetics and molecular dynamics simulation study. Int J Biol Macromol. 2017 Dec;105(Pt 3):1654-1662.
Smiles	O=C(C(O)=O)CCC(O)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Alpha-Ketoglutaric acid,2-Oxoglutaric acid
Shipping Condition	Room temperature
Available
Manufacturer - Type	Natural Products
Manufacturer - Applications	Metabolism-sugar/lipid metabolism
Manufacturer - Targets	Endogenous Metabolite; Tyrosinase
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	146.10
Product Description	2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM)[1].
Manufacturer - Research Area	Metabolic Disease; Neurological Disease
Solubility	DMSO: 250 mg/mL (ultrasonic)\|H2O: 50 mg/mL (ultrasonic)
Manufacturer - Pathway	Metabolic Enzyme/Protease
Isoform	Human Endogenous Metabolite; Microbial Metabolite
Clinical information	No Development Reported

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HY-W013636-500mg-safety-datasheet.pdf