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5,15-Diphenylporphyrin

5,15-Diphenylporphyrin

Item no.	HY-W035137-50mg
Manufacturer	MedChem Express
CASRN	22112-89-6
Amount	50 mg
Quantity options	100 mg 10 mg 1 ea 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitor
Specific against	other
Purity	95.0
Citations	[1]Uehara Y, et al. Novel high-throughput screening system for identifying STAT3-SH2 antagonists. Biochem Biophys Res Commun. 2009;380(3):627-631. \|[2]Xiang F, et al. Coverage-induced chiral transition of Co (II)-5, 15-diphenylporphyrin self-assemblies on Cu (111)[J]. The Journal of Physical Chemistry C, 2022, 126(15): 6745-6752.
Smiles	C1(/C2=CC=CC=C2)=C3C=CC(/C=C4C=C/C(N/4)=C(C5=CC=CC=C5)/C(C=C/6)=NC6=C/C7=CC=C1N7)=N/3
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	5,15-DPP
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Targets	STAT
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, protect from light)
Molecular Weight	462.54
Product Description	5, 15-Diphenylporphyrin (5, 15-DPP) is an inhibitor of the oncogenic transcription factor STAT3. 5, 15-Diphenylporphyrin specifically binds to the SH2 domain of STAT3, blocking the pTyr-SH2 interaction, thereby inhibiting the dimerization, nuclear translocation and DNA binding activity of STAT3, and ultimately inhibiting the expression of cancer cell-related genes. 5, 15-Diphenylporphyrin can be used in research fields related to the development of anticancer drugs[1][2].
Manufacturer - Research Area	Cancer
Solubility	DMSO: 2 mg/mL (ultrasonic; warming; heat to 60°C)
Manufacturer - Pathway	JAK/STAT Signaling; Stem Cell/Wnt
Clinical information	No Development Reported

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HY-W035137-50mg-safety-datasheet.pdf