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Phosphatidylglycerols (egg) (sodium salt)

Phosphatidylglycerols (egg) (sodium salt)

Item no.	HY-W251428-100mg
Manufacturer	MedChem Express
CASRN	383907-64-0
Amount	100 mg
Quantity options	100 mg 1 ea 25 mg 50 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.92
Citations	[1]Chen WW, et al. Phosphatidylglycerol Incorporates into Cardiolipin to Improve Mitochondrial Activity and Inhibits Inflammation. Sci Rep. 2018 Mar 20;8(1):4919.\|[2]Numata M, et al. Pulmonary surfactant phosphatidylglycerol inhibits respiratory syncytial virus-induced inflammation and infection. Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):320-5.\|[3]Poelma DL, et al. Influence of phosphatidylglycerol on the uptake of liposomes by alveolar cells and on lung function. J Appl Physiol (1985). 2005 May;98(5):1784-91.
Smiles	CCCCCCCCCCCCCCCC(OC[C@](CC(CCCCCCC/C=C\CCCCCCCC)=O)(C)COP(OCC(O)CO)(O[Na])=O)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Egg PG
Shipping Condition	Room temperature
Available
Manufacturer - Type	Biochemical Assay Reagents
Manufacturer - Targets	Biochemical Assay Reagents
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	783.04
Product Description	Phosphatidylglycerols (PG) is a selective inhibitor targeting the TLR4 accessory protein CD14/MD-2 complex, inhibiting LPS or virus (such as RSV)-mediated inflammatory signaling pathways through competitive binding. Phosphatidylglycerols directly bind to viral particles to block infection, inhibit COX-2 expression to reduce the release of inflammatory factors (IL-6, IL-8), and improve oxidative stress by regulating mitochondrial membrane phospholipid remodeling. Phosphatidylglycerols can be taken orally or by inhalation and can be used in the study of chronic inflammatory diseases (such as atherosclerosis) and respiratory viral infections (such as RSV)[1][2][3].
Manufacturer - Research Area	Others
Solubility	DMSO: 10 mg/mL (ultrasonic; warming; heat to 60°C)
Manufacturer - Pathway	Others
Clinical information	No Development Reported

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HY-W251428-100mg-safety-datasheet.pdf