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Roxadustat (FG-4592)

Roxadustat (FG-4592)

Item no.	S1007-10
Manufacturer	Selleckchem
CASRN	808118-40-3
Amount	10 mg
Quantity options	10 mg 1 g 10 g 10 mM/1 mL 200 mg 50 mg 5 g
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Smiles	CC1=C2C=C(C=CC2=C(C(=N1)C(=O)NCC(=O)O)O)OC3=CC=CC=C3
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	ASP1517
Similar products	FG-4592
Available
Storage Conditions	2 years -80 in solvent
Molecular Weight	352, 34
Clinical Trials	A phase II clinical trial of FG-4592 has been competed in the treatment of chronic kidney disease.
In vitro	FG-4592 is an oral inhibitor of hypoxia inducible factor (HIF) prolyl hydroxylase currently in clinical development for the treatment of anemia. FG-4592 stabilizes the activities of HIF, a cytosolic transcription factor, leading to activation of the genes associated with erythropoiesis, including erythropoietin and enzymes involved in iron metabolism. [1]
Solubility (25C)	DMSO 71 mg/mL, Water <1 mg/mL, Ethanol <1 mg/mL
Information	Roxadustat (FG-4592) is an HIF-α prolyl hydroxylase inhibitor in a cell-free assay, stabilizes HIF-2 and induces EPO production. Roxadustat potentiates RSL3 induced ferroptosis. Phase 3.
Chemical Name	2-(4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carboxamido)acetic acid

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S1007-10-datasheet.pdf

S1007-10-safety-datasheet.pdf