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Afatinib

Afatinib

Item no.	S1011-25
Manufacturer	Selleckchem
CASRN	850140-72-6
Amount	25 mg
Quantity options	10 mg 1 g 10 g 10 mM/1 mL 200 mg 25 mg 5 mg 50 mg 500 mg 5 g
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Smiles	CN(C)CC=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OC4CCOC4
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	BIBW2992
Available
Manufacturer - Targets	EGFR
Storage Conditions	2 years -80 in solvent
Information	Afatinib inhibits EGFR/ErbB irreversibly in vitro with IC50 of 0.5, 0.4, 10, 14, 1 nM for EGFRwt, EGFR L858R , EGFR L858R/T790M ErbB2 (HER2) and ErbB4 (HER4), respectively. Afatinib induces autophagy.
Pathway	Protein Tyrosine Kinase

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

S1011-25-datasheet.pdf

S1011-25-safety-datasheet.pdf