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Lenalidomide

Lenalidomide

Item no.	S1029-200
Manufacturer	Selleckchem
CASRN	191732-72-6
Amount	200 mg
Quantity options	10 mg 1 g 10 g 10 mM/1 mL 200 mg 50 mg 500 mg 5 g
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Smiles	C1CC(=O)NC(=O)C1N2CC3=C(C2=O)C=CC=C3N
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	CC-5013
Available
Manufacturer - Targets	E3 ligase Ligand
Storage Conditions	2 years -80 in solvent
Information	Lenalidomide is a TNF-α secretion inhibitor with IC50 of 13 nM in PBMCs. Lenalidomide (CC-5013) is a ligand of ubiquitin E3 ligase cereblon (CRBN), and it causes selective ubiquitination and degradation of two lymphoid transcription factors, IKZF1 and IKZF3, by the CRBN-CRL4 ubiquitin ligase. Lenalidomide promotes cleaved caspase-3 expression and inhibit VEGF expression and induces apoptosis.
Pathway	Ubiquitin

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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Request Data Sheet

S1029-200-datasheet.pdf

S1029-200-safety-datasheet.pdf