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Sorafenib tosylate

Sorafenib tosylate

Item no.	S1040-300
Manufacturer	Selleckchem
CASRN	475207-59-1
Amount	300 mg
Quantity options	10 mg 100 mg 1 g 10 g 10 mM/1 mL 200 mg 300 mg 5 mg 50 mg 500 mg 5 g
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Smiles	CC1=CC=C(C=C1)S(=O)(=O)O.CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	BAY 43-9006 tosylate,NSC-724772 tosylate
Available
Manufacturer - Targets	Raf
Storage Conditions	2 years -80 in solvent
Information	Sorafenib tosylate is a multikinase inhibitor of Raf-1 and B-Raf with IC50 of 6 nM and 22 nM in cell-free assays, respectively. Sorafenib Tosylate inhibits VEGFR-2, VEGFR-3, PDGFR-β, Flt-3 and c-KIT with IC50 of 90 nM, 20 nM, 57 nM, 59 nM and 68 nM, respectively. Sorafenib Tosylate induces autophagy and apoptosis and activates ferroptosis with anti-tumor activity.
Pathway	MAPK

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Request Data Sheet

S1040-300-datasheet.pdf

S1040-300-safety-datasheet.pdf