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o-Phenanthroline

o-Phenanthroline

Item no.	S6830-25
Manufacturer	Selleckchem
CASRN	66-71-7
Amount	25 mg
Quantity options	100 mg 25 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Smiles	C1=CC2=C(C3=C(C=CC=N3)C=C2)N=C1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1,10-Phenanthroline,phen
Available
Manufacturer - Targets	MMP
Storage Conditions	3 years -20°C powder
Information	o-Phenanthroline (1, 10-Phenanthroline, phen), a hypoxia-mimicking agent, is a non-specific matrix metalloproteinase (MMP) inhibitor with IC50 of 110.5μM for Collagenase. O-phenanthroline reduces the expression of MMP3 and MMP13 mRNA levels during chondrogenic differentiation of human chondrocytes (hChs), as well as after TNFα/IL-1β exposure in an explant model. o-Phenanthroline is also a metal chelator which prevents the induction of chromosomal aberrations in streptozotocin-treated cells and forms a red chelate with Fe2+ that absorbs maximally at 510 nm.
Pathway	Proteases

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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Request Data Sheet

S6830-25-datasheet.pdf

S6830-25-safety-datasheet.pdf