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CMPD101

CMPD101

Item no.	TMO-T14989-100mg
Manufacturer	TargetMol
CASRN	865608-11-3
Amount	100 mg
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 1 mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	0,9901
Formula	C24H21F3N6O
Smiles	Cn1c(CNc2cccc(c2)C(=O)NCc2ccccc2C(F)(F)F)nnc1-c1ccncc1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	ROCK,GRK,PKC
Shipping Condition	Cool pack
Available
Manufacturer - Targets	ROCK\|\|\|PKC\|\|\|GRK
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	466.46
Description	CMPD101 is a membrane-permeable small-molecule inhibitor of GRK2/3 (IC50: 18 nM and 5.4 nM). Which can be used for the study of heart failure. CMPD101 exhibits less selectively against GRK1, GRK5, ROCK-2 and PKCα with IC50s of 3.1 μM , 2.3 μM, 1.4 μM and 8.1 μM, respectively.
Pathways	GPCR/G Protein\|\|\|Cytoskeletal Signaling\|\|\|Cell Cycle/Checkpoint\|\|\|Chromatin/Epigenetic\|\|\|Stem Cells
Bioactivity	CMPD101 is a membrane-permeable small-molecule inhibitor of GRK2/3 (IC50: 18 nM and 5.4 nM). Which can be used for the study of heart failure. CMPD101 exhibits less selectively against GRK1, GRK5, ROCK-2 and PKCÎ± with IC50s of 3.1 Î¼M , 2.3 Î¼M, 1.4 Î¼M and 8.1 Î¼M, respectively.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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