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KDM5-C70

KDM5-C70

Item no.	TMO-T15648-10mM
Manufacturer	TargetMol
CASRN	1596348-32-1
Amount	1 mL x 10 mM (in DMSO)
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 1 mL 1 mg 200 mg 25 mg 2 mg 500 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.00%
Citations	Johansson C, et al. Structural analysis of human KDM5B guides histone demethylase inhibitor development. Nat Chem Biol. 2016 Jul;12(7):539-45.
Smiles	CCOC(=O)c1ccnc(CNCC(=O)N(CC)CCN(C)C)c1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1596348-32-1
Shipping Condition	Cool pack
Available
Manufacturer - Targets	Histone Demethylase
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	336.43
Description	KDM5-C70 is an ethyl ester derivative of KDM5-C49 and functions as an effective, cell-permeable, pan-KDM5 histone demethylase inhibitor. It exhibits an antiproliferative effect in myeloma cells and induces a genome-wide elevation of H3K4me3 levels.
Pathways	Chromatin/Epigenetic
Bioactivity	KDM5-C70 is an ethyl ester derivative of KDM5-C49. KDM5-C70 is an effective, cell-permeable, and pan-KDM5 histone demethylase inhibitor. KDM5-C70 has an antiproliferative effect in myeloma cells, inducing a genome-wide elevation of H3K4me3 levels.
Receptor	KDM5 histone demethylase

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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TMO-T15648-10mM-datasheet.pdf

TMO-T15648-10mM-safety-datasheet.pdf