Comparison

PBIT European Partner

Manufacturer TargetMol
Category
Type Inhibitors
Specific against other
Amount 1mL*10mM(inDMSO)
Item no. TMO-T16435-10mM
eClass 6.1 30220300
eClass 9.0 32160605
Available
purity
99.95%
SMILES
O=C1N(C2=CC=C(C)C=C2)SC3=C1C=CC=C3
formula
C14H11NOS
MolWt
241.31
Pathway
Chromatin/Epigenetic
Target
Histone Methyltransferase
Receptor
JARID1A; JARID1B; JARID1C
Bioactivity
PBIT inhibits JARID1B histone demethylase (IC50 of about 3 uM). PBIT also inhibits JARID1A and JARID1C (IC50s of 6 uM and 4.9 uM, respectively). PBIT is a specific inhibitor of the Jumonji AT-rich Interactive Domain 1 (JARID1) enzymes .
Reference
Sayegh J, et al. Identification of small molecule inhibitors of Jumonji AT-rich interactive domain 1B (JARID1B) histone demethylase by a sensitive high throughput screen. J Biol Chem. 2013 Mar 29; 288(13):9408-17.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 1mL*10mM(inDMSO)
Available: In stock
available

Delivery expected until 6/6/2024 

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