PBIT

Item no.	TMO-T16435-10mM
Manufacturer	TargetMol
CASRN	2514-30-9
Amount	1 mL x 10 mM (in DMSO)
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 1 mg 200 mg 25 mg 2 mg 500 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.95%
Citations	Sayegh J, et al. Identification of small molecule inhibitors of Jumonji AT-rich interactive domain 1B (JARID1B) histone demethylase by a sensitive high throughput screen. J Biol Chem. 2013 Mar 29;288(13):9408-17.
Smiles	CC1=CC=C(C=C1)N1SC2=CC=CC=C2C1=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	2514-30-9,Histone Methyltransferase
Shipping Condition	Cool pack
Available
Manufacturer - Targets	Histone Demethylase\|\|\|Histone Methyltransferase
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	241.31
Description	PBIT inhibits JARID1B histone demethylase (IC50 of about 3 μM). PBIT also inhibits JARID1A and JARID1C (IC50s of 6 μM and 4.9 μM, respectively). PBIT is a specific inhibitor of the Jumonji AT-rich Interactive Domain 1 (JARID1) enzymes .
Pathways	Chromatin/Epigenetic
Bioactivity	PBIT inhibits JARID1B histone demethylase (IC50 of about 3 uM). PBIT also inhibits JARID1A and JARID1C (IC50s of 6 uM and 4.9 uM, respectively). PBIT is a specific inhibitor of the Jumonji AT-rich Interactive Domain 1 (JARID1) enzymes .
Receptor	JARID1A; JARID1B; JARID1C

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 1 mL x 10 mM (in DMSO)

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