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TH287 hydrochloride

TH287 hydrochloride

Item no.	TMO-T2069L-10mg
Manufacturer	TargetMol
CASRN	1638211-05-8
Amount	10 mg
Quantity options	1 mL x 10 mM (in DMSO) 10 mg 1 mg 25 mg 2 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.00%
Citations	Saleh A, et, al. Development and validation of method for TH588 and TH287, potent MTH1 inhibitors and new anti-cancer agents, for pharmacokinetic studies in mice plasma. J Pharm Biomed Anal. 2015 Feb;104:1-11.
Smiles	NC1=NC(C2=CC=CC(Cl)=C2Cl)=CC(NC)=N1.[H]Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1638211-05-8,MTH1
Shipping Condition	Cool pack
Available
Manufacturer - Targets	DNA/RNA Synthesis\|\|\|MTH1
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	305.59
Description	TH287 is a selective MTH1 inhibitor(IC50 : 0.8 nM). It causees incorporation of oxidized dNTPs in cancer cells, leading to DNA damage, cytotoxicity and therapeutic responses in patient-derived mouse xenografts.
Pathways	Cell Cycle/Checkpoint\|\|\|DNA Damage/DNA Repair

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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