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(S)-AMG-510

(S)-AMG-510

Item no.	TMO-T22258-100mg
Manufacturer	TargetMol
CASRN	2252403-56-6
Amount	100 mg
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 200 mg 25 mg 2 mg 500 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.57%
Citations	Canon J , Rex K , Saiki A Y , et al. The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity[J]. Nature, 2019, 575(7781).
Smiles	O=C1N(C=2C(C(=N1)N3[C@@H](C)CN(C(C=C)=O)CC3)=CC(F)=C(N2)C4=C(F)C=CC=C4O)C5=C(C(C)C)N=CC=C5C
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	AMG-510 racemate
Shipping Condition	Cool pack
Available
Manufacturer - Targets	Kras
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	560.594
Description	(S)-AMG-510 is the S-type compound of AMG-510 (Sotorasib), which effectively and selectively inhibits KRASG12C through covalent interaction with mutant cysteine, thereby promoting clinical efficacy in KRASG12C tumors.
Pathways	GPCR/G Protein\|\|\|MAPK

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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