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Bimiralisib

Bimiralisib

Item no.	TMO-T2265-500mg
Manufacturer	TargetMol
CASRN	1225037-39-7
Amount	500 mg
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 1 mg 1 mL 25 mg 2 mg 500 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Smiles	Nc1cc(c(cn1)-c1nc(nc(n1)N1CCOCC1)N1CCOCC1)C(F)(F)F
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	5-(4,6-dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine,PQR309,PI3K-IN-2
Shipping Condition	Cool pack
Available
Manufacturer - Targets	PI3K\|\|\|S6 Kinase\|\|\|mTOR
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	411.38
Description	Bimiralisib (PI3K-IN-2) is an orally bioavailable pan inhibitor of PI3K and inhibitor of the mTOR, with potential antineoplastic activity. PI3K-IN-2 inhibits the PI3K kinase isoforms alpha, beta, gamma and delta and, to a lesser extent, mTOR kinase, which may result in tumor cell apoptosis and growth inhibition in cells overexpressing PI3K/mTOR. Activation of the PI3K/mTOR pathway promotes cell growth, survival, and resistance to both chemotherapy and radiotherapy.
Pathways	PI3K/Akt/mTOR signaling\|\|\|MAPK

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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