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PKR-IN-C51

PKR-IN-C51

Item no.	TMO-T24647-5mg
Manufacturer	TargetMol
CASRN	1314594-23-4
Amount	5 mg
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 200 mg 25 mg 2 mg 500 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	0,98
Formula	C23H21N5
Smiles	N1=CC=C(N=C1NCCC2=CNC=3C=CC=CC32)C=4C=5C=CC=CC5NC4C
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	PKR-inhibitor-C51,PKRINC51,PKR inhibitor C51,PKR IN C51
Shipping Condition	Cool pack
Available
Manufacturer - Targets	Serine/threonin kinase
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	367.45
Description	PKR-IN-C51 is a dose-dependent and ATP-competitive protein kinase R (PKR) inhibitor that inhibits intracellular PKR activation and autophosphorylation in mouse macrophages with an IC50=9 μM and Ki=3.4 μM.Interferon-induced double-stranded RNA-activated protein kinase (PKR) is a widely expressed Ser/Thr kinase.
Pathways	Metabolism\|\|\|Cell Cycle/Checkpoint
Bioactivity	PKR-IN-C51 is an inhibitor of protein kinase R. It acts by correcting the aberrant splicing of MBNL1-dependent pre-mRNAs in DM1 cells without affecting the splicing pattern in normal non-DM1 cells.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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