Comparison

Isorhamnetin European Partner

Item no. TMO-T2836-500mg
Manufacturer TargetMol
CASRN 480-19-3
Amount 500 mg
Quantity options 100 mg 1 mL x 10 mM (in DMSO) 10 mg 1 mg 1 mL 250 mg 25 mg 2 mg 500 mg 50 mg 5 mg
Category
Type Inhibitors
Specific against other
Smiles COc1cc(ccc1O)-c1oc2cc(O)cc(O)c2c(=O)c1O
ECLASS 10.1 32160490
ECLASS 11.0 32160490
UNSPSC 12000000
Alias 3-methylquercetin,3'-Methylquercetin,Isorhamnetol,3'-Methoxyquercetin
Shipping Condition Cool pack
Available
Manufacturer - Targets
PI3K|||MEK|||Endogenous Metabolite
Shipping Temperature
Cool pack
Storage Conditions
-20
Molecular Weight
316.26
Description
Isorhamnetin (3-methylquercetin) is the methylated metabolite of quercetin. Quercetin is an important dietary flavonoid with in vitro antioxidant activity. Isorhamnetin prevents endothelial cell injuries from oxidized LDL via inhibition of lectin-like ox-LDL receptor-1 upregulation, interference of ox-LDL-mediated intracellular signaling pathway (p38MAPK activation, NF-kappaB nuclear translocation, eNOS expression) and the antioxidant activity of isorhamnetin. Isorhamnetin prevents endothelial dysfunction, superoxide production, and overexpression of p47phox induced by angiotensin II. Isorhamnetin appears to be a potent drug against esophageal cancer due to it's in vitro potential to not only inhibit proliferation but also induce apoptosis of Eca-109 cells.
Pathways
PI3K/Akt/mTOR signaling|||Metabolism|||MAPK

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 500 mg
Available: In stock
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