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Euphorbia factor L1

Euphorbia factor L1

Item no.	TMO-T2S0410-200mg
Manufacturer	TargetMol
CASRN	76376-43-7
Amount	200 mg
Quantity options	100 mg 100 mg 1 mL x 10 mM (in DMSO) 1 mL x 10 mM (in DMSO) 10 mg 10 mg 1 mg 1 mL 200 mg 20 mg 25 mg 25 mg 2 mg 2 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	0,98
Formula	C32H40O8
Smiles	O(C(C)=O)[C@]12[C@@]([C@@H](OC(C)=O)[C@@]3(CO3)CC[C@]4([C@@](\C=C(\C)/C1=O)(C4(C)C)[H])[H])([C@@H](OC(CC5=CC=CC=C5)=O)[C@@H](C)C2)[H]
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Euphorbiasteroid
Shipping Condition	Cool pack
Available
Manufacturer - Targets	P-gp\|\|\|Apoptosis
Shipping Temperature	Cool pack
Storage Conditions	-20°C
Molecular Weight	552, 66
Description	Euphorbia factor L1 (Euphorbiasteroid) can reduce Bcl-2, PI3K, AKT, and mTOR protein and mRNA levels, and up-regulate caspase-9 and caspase-3 protein levels. It induces autophagy and has anti-cancer, anti-adipogenic, anti-osteoclastogenic, and multidrug-resistant regulatory effects.
Pathways	Membrane transporter/Ion channel\|\|\|Apoptosis\|\|\|Neuroscience
Bioactivity	1. Euphorbia factor L1 can enhance the ATP hydrolysis activity of ABCB1 stimulated by verapamil. 2. Euphorbia factor L1 inhibits the efflux of ABCB1 in KBv200 and MCF-7/adr cells, does not downregulate their expression either in mRNA or protein level.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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