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NLRP3-IN-2

NLRP3-IN-2

Item no.	TMO-T3230-100mg
Manufacturer	TargetMol
CASRN	16673-34-0
Amount	100 mg
Quantity options	1000 mg 100 mg 1 mL x 10 mM (in DMSO) 1 g 1 mL 200 mg 25 mg 500 mg 50 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.44%
Citations	Marchetti, C., Chojnacki, J., Toldo, S., Mezzaroma, E., Tranchida, N., & Rose, S. et al. (2014). A Novel Pharmacologic Inhibitor of the NLRP3 Inflammasome Limits Myocardial Injury After Ischemia-Reperfusion in the Mouse.?Journal Of Cardiovascular Pharmacology,?63(4), 316-322. doi: 10.1097/fjc.202002020020200200020053
Smiles	COc1ccc(Cl)cc1C(=O)NCCc1ccc(cc1)S(N)(=O)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	5-Chloro-N-(p-sulfamoylphenethyl)-o-anisamide,NLRP3 Inflammasome Inhibitor I
Shipping Condition	Cool pack
Available
Manufacturer - Targets	NOD-like Receptor (NLR)\|\|\|NOD
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	368.84
Description	NLRP3-IN-2 (5-Chloro-N-(p-sulfamoylphenethyl)-o-anisamide), an intermediate capable of synthesizing glibenclamide, exerts an inhibitory effect on the formation of NLRP3 inflammatory vesicles in cardiomyocytes, limiting infarct size after myocardial ischemia/reperfusion in mice and has no effect on metabolism.
Pathways	NF-κB\|\|\|Immunology/Inflammation

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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