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AZ 12799734

AZ 12799734

Item no.	TMO-T35896-10mg
Manufacturer	TargetMol
CASRN	1117684-36-2
Amount	10 mg
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 1 mg 200 mg 25 mg 500 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	0,98
Formula	C18H18N4O3S
Smiles	O(C=1C=C(NC2=CC=C(S(N)(=O)=O)C=C2)N=CC1)C3=C(C)N=C(C)C=C3
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	AZ12799734
Shipping Condition	Cool pack
Available
Manufacturer - Targets	ALK
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	370.43
Description	AZ 12799734 is an orally active, selective and potent dual inhibitor of TGFBR1 and ALK5 with inhibitory effects on BMP and TGFβ for the study of tumours.
Pathways	Tyrosine Kinase/Adaptors\|\|\|Angiogenesis
Bioactivity	Potent inhibitor of transforming growth factor-Î² type I receptor (TGF-Î²RI; ALK5) (IC50 = 17 nM in cellular inhibition assay and 47 nM in TGF-Î²-induced luciferase activity assay). Also inhibits ALK4, ALK6 and ALK7 at concentrations under 10 Î¼M. Inhibits BMP signaling, phosphorylation of SMAD1 and SMAD2, and TGF-Î²-induced epithelial cell migration in vitro. Displays cardiotoxicity in vivo. Orally bioavailable.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 10 mg

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