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NVS-PAK1-C

NVS-PAK1-C

Item no.	TMO-T35928-1mg
Manufacturer	TargetMol
CASRN	2250019-95-3
Amount	1 mg
Quantity options	100 mg 1 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	0,98
Smiles	C(C(F)F)N1C=2C(C(N[C@@H]3CN(C(N(C)C)=O)CC3)=NC=4C1=CC=C(F)C4)=CC(Cl)=CC2
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	NVS-PAK1-C
Shipping Condition	Cool pack
Available
Manufacturer - Targets	Others
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	465.9
Description	NVS-PAK1-1 is a potent allosteric inhibitor of PAK1 with an IC 50 of 5 nM for dephosphorylated PAK1 and 6 nM for phosphorylated PAK1 as assessed. Inhibition is ATP-competitive, most likely due to indirect competition due to incompatibility of ATP binding with the DFG-out binding conformation of the allosteric compound. NVS-PAK1-1 has an IC50 of 270 nM against dephosphorylated PAK2 and 720 nM against phosphorylated PAK2 respectively [1].
Pathways	Others
Bioactivity	NVS-PAK1-C is a negative control for the allosteric PAK1 inhibitor NVS-PAK1-1 . See the Structural Genomic Consortium (SGC) website for more information.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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