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Endosidin-2

Endosidin-2

Item no.	TMO-T37020-5mg
Manufacturer	TargetMol
CASRN	1839524-44-5
Amount	5 mg
Quantity options	100 mg 10 mg 1 mL 25 mg 500 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitor
Specific against	other
Purity	0,98
Formula	C15H12FIN2O3
Smiles	COC1=CC(\C=N\NC(=O)C2=CC=CC(F)=C2)=CC(I)=C1O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	ES2, Endosidin 2
Shipping condition	Cool pack
Available
Shipping Temperature	cool pack
Storage Conditions	-20°
Molecular Weight	414, 17
Target names or alias	ES2
Description	Endosidin-2 is an exocyst inhibitor, a cell-permeable benzylidene benzoylhydrazine, that binds to the exocyst component of the 70 kDa (EXO70) subunit of the exocyst complex (Kd = 253 μM, EXO70A1).Endosidin-2 disrupts protein translocation between the endosomes and plasma membrane, thereby facilitating translocation of proteins to the vesicle for degradation. It also inhibits recirculation of endocytosed transferrin to the plasma membrane in HeLa cells and targets multiple isoforms of mammalian EXO70, leading to dysregulation of exocytosis.Endosidin2 can be used as a tool molecule to study cytosolization.
Pathways	Others

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