TML-6

Item no.	TMO-T37148-10mg
Manufacturer	TargetMol
CASRN	1462868-88-7
Amount	10 mg
Quantity options	100 mg 100 mg 10 mg 25 mg 25 mg 50 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	0,98
Formula	C30H37NO7
Smiles	CCN(CC)C(=O)CC(C)(C(=O)\C=C\c1ccc(OC)c(OC)c1)C(=O)\C=C\c1ccc(OC)c(OC)c1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Shipping Condition	Cool pack
Available
Manufacturer - Targets	Others\|\|\|Nrf2\|\|\|mTOR\|\|\|Beta Amyloid\|\|\|NF-κB
Shipping Temperature	Cool pack
Storage Conditions	-20°C
Molecular Weight	523, 62
Description	TML-6, an oral curcumin derivative, demonstrates inhibitory effects on the synthesis of β-amyloid precursor protein and β-amyloid (Aβ). Additionally, TML-6 exhibits upregulation of Apo E, suppression of NF-κB and mTOR, and enhancement of the anti-oxidative Nrf2 gene activity. Considering its diverse pharmacological profile, TML-6 holds promise as a valuable research tool for investigating Alzheimer's disease (AD)[1].
Pathways	NF-κB\|\|\|Immunology/Inflammation\|\|\|PI3K/Akt/mTOR signaling\|\|\|Neuroscience\|\|\|Others
Bioactivity	TML-6, an orally active curcumin derivative, inhibits the synthesis of the Î²-amyloid precursor protein and Î²-amyloid (AÎ²). TML-6 can upregulate Apo E, suppress NF-ÎºB and mTOR, and increase the activity of the anti-oxidative Nrf2 gene. TML-6 has the potential for Alzheimerâ€™s disease (AD) research[1].

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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