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Sitamaquine tosylate

Sitamaquine tosylate

Item no.	TMO-T37469-10mg
Manufacturer	TargetMol
CASRN	1019640-33-5
Amount	10 mg
Quantity options	100 mg 10 mg 1 mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	0,98
Formula	C21H33N3O?C7H8O3S
Smiles	Cc1ccc(cc1)S(O)(=O)=O.CCN(CC)CCCCCCNc1cc(OC)cc2c(C)ccnc12
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Shipping Condition	Cool pack
Available
Manufacturer - Targets	Others
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	515.71
Description	Sitamaquine is an antileishmanial agent.1It is active againstL. donovani, L. infantum, L. mexicana, L. braziliensis, andL. tropica(EC50s = 9.5-19.8 μM). It inhibits mitochondrial complex II, also known as succinate dehydrogenase (SDH), in a cell-free assay when used at concentrations ranging from 10 to 200 μM.2Sitamaquine (100 μM) increases intracellular levels of reactive oxygen species (ROS) and decreases intracellular ATP levels, as well as induces phosphatidylserine externalization, chromatin fragmentation, and depolarization of the mitochondrial membrane potential, markers of apoptosis, inL. donovanipromastigotes.
Pathways	Others
Bioactivity	Sitamaquine is an antileishmanial agent.1It is active againstL. donovani, L. infantum, L. mexicana, L. braziliensis, andL. tropica(EC50s = 9.5-19.8 Î¼M). It inhibits mitochondrial complex II, also known as succinate dehydrogenase (SDH), in a cell-free assay when used at concentrations ranging from 10 to 200 Î¼M.2Sitamaquine (100 Î¼M) increases intracellular levels of reactive oxygen species (ROS) and decreases intracellular ATP levels, as well as induces phosphatidylserine externalization, chromatin fragmentation, and depolarization of the mitochondrial membrane potential, markers of apoptosis, inL. donovanipromastigotes.

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