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STING Agonist 1a

STING Agonist 1a

Item no.	TMO-T38160-1mg
Manufacturer	TargetMol
CASRN	652142-94-4
Amount	1 mg
Quantity options	100 mg 10 mg 1 mg 500 ug 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	0,98
Formula	C19H11Cl2N5O
Smiles	ClC=1C=2N(C(=NN2)C3=CC4=C(N=C3Cl)C=CC(OC)=C4)C=5C(N1)=CC=CC5
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Shipping Condition	Cool pack
Available
Manufacturer - Targets	Others
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	396.23
Description	STING agonist 1a is an agonist of stimulator of interferon genes (STING).1It induces expression of an IRF-inducible SEAP reporter gene in a cell-based assay (EC50= 16.77 μM). STING agonist 1a (12.5-100 μM) induces expression of IFN-β, IL-6, and chemokine (C-X-C motif) ligand 10 (CXCL10) in THP-1 cells, an effect that can be reversed by STING knockout or the STING inhibitor H-151 .
Pathways	Others
Bioactivity	STING agonist 1a is an agonist of stimulator of interferon genes (STING).1It induces expression of an IRF-inducible SEAP reporter gene in a cell-based assay (EC50= 16.77 Î¼M). STING agonist 1a (12.5-100 Î¼M) induces expression of IFN-Î², IL-6, and chemokine (C-X-C motif) ligand 10 (CXCL10) in THP-1 cells, an effect that can be reversed by STING knockout or the STING inhibitor H-151 .

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