R-8507

Manufacturer	TargetMol
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitor
Specific against	other
Amount	25mg
Item no.	TMO-T38339-25mg
CASRN	338773-13-0
eClass 6.1	30220300
eClass 9.0	32160605
Available
Bioactivity	R-8507 is a small molecule antagonist of the TNF-α type 1 receptor (TNF-αRI). It inhibits the expression of intercellular adhesion molecule-1 (ICAM-1) induced by TNF-α and IL-1β with EC50 values of 2.45 and 3.79 μM, respectively, in an ELISA using A549 lung epithelial cells. It also disrupts the interaction of the TNF-αRI with receptor interacting protein 1 (RIP1) and TNF-αR-associated death domain protein (TRADD), preventing internalization of the receptor complex.
Molwt	348, 71

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Amount: 25mg

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Delivery expected until 5/23/2024