E7449

Item no.	TMO-T4471-10mg
Manufacturer	TargetMol
CASRN	1140964-99-3
Amount	10 mg
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 1 mg 200 mg 25 mg 2 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	97.13%
Citations	McGonigle S, Chen Z, Wu J, et al. E7449: A dual inhibitor of PARP1/2 and tankyrase1/2 inhibits growth of DNA repair deficient tumors and antagonizes Wnt signaling. Oncotarget. 2015;6(38):41307-41323. doi:10.18632/oncotarget.5846
Smiles	O=c1[nH][nH]c2nc(CN3Cc4ccccc4C3)nc3cccc1c23
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Stenoparib,UNII-9X5A2QIA7C
Shipping Condition	Cool pack
Available
Manufacturer - Targets	PARP
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	317.34
Description	E7449 (UNII-9X5A2QIA7C) is a potent PARP1 and PARP2 inhibitor and also inhibits TNKS1 and TNKS2, with IC50s of 2.0, 1.0, ～50 and ～50 nM for PARP1, PARP2, TNKS1 and TNKS2, respectively, using 32P-NAD+ as substrate.
Pathways	DNA Damage/DNA Repair\|\|\|Chromatin/Epigenetic

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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