FM-381

Item no.	TMO-T5091-100mg
Manufacturer	TargetMol
CASRN	2226521-65-7
Amount	100 mg
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 1 mg 25 mg 2 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Smiles	CN(C)C(=O)C(=C\c1ccc(o1)-c1nc2cnc3[nH]ccc3c2n1C1CCCCC1)\C#N
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	FM381
Shipping Condition	Cool pack
Available
Manufacturer - Targets	JAK
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	428.49
Description	FM381 is a potent covalent reversible inhibitor of JAK3. FM-381 has an IC50 of 127 pM for JAK3, with 410, 2700 and 3600-fold selectivity over JAK1, JAK2 and TYK2, respectively.
Pathways	Angiogenesis\|\|\|Tyrosine Kinase/Adaptors\|\|\|Chromatin/Epigenetic\|\|\|JAK/STAT signaling\|\|\|Stem Cells

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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