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Rosmanol

Rosmanol

Item no.	TMO-T7033-2mg
Manufacturer	TargetMol
CASRN	80225-53-2
Amount	2 mg
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 1 mg 25 mg 2 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	0,9882
Formula	C20H26O5
Smiles	[H][C@]12OC(=O)[C@@]3(CCCC(C)(C)[C@]13[H])c1c(O)c(O)c(cc1[C@@H]2O)C(C)C
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Antioxidant,COX
Shipping Condition	Cool pack
Available
Manufacturer - Targets	COX\|\|\|Antioxidant
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	346.42
Description	Rosmanol has antioxidant activity, it can activate the antioxidant response element. Rosmanol has biphasic modulation of GABAA receptors, demonstrates CNS activity in mouse models of antinociception, antidepressant and anxiolysis. Rosmanol potently induces apoptosis through both the mitochondrial apoptotic pathway and death receptor pathway in human colon adenocarcinoma COLO 205 cells. Rosmanol has anti-inflammatory activity, it potently inhibits lipopolysaccharide-induced iNOS and COX-2 expression through downregulating MAPK, NF-kappaB, STAT3 and C/EBP signaling pathways.
Pathways	Oxidation-Reduction\|\|\|Neuroscience\|\|\|Immunology/Inflammation
Bioactivity	Rosmanol has antioxidant activity, it can activate the antioxidant response element. Rosmanol has biphasic modulation of GABAA receptors, demonstrates CNS activity in mouse models of antinociception, antidepressant and anxiolysis. Rosmanol potently induces apoptosis through both the mitochondrial apoptotic pathway and death receptor pathway in human colon adenocarcinoma COLO 205 cells. Rosmanol has anti-inflammatory activity, it potently inhibits lipopolysaccharide-induced iNOS and COX-2 expression through downregulating MAPK, NF-kappaB, STAT3 and C/EBP signaling pathways.

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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