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N-piperidine Ibrutinib

N-piperidine Ibrutinib

Item no.	TMO-T9408-5mg
Manufacturer	TargetMol
CASRN	330785-90-5
Amount	5 mg
Quantity options	100 mg 100 mg 10 mg 10 mg 1 mg 1 mg 200 mg 200 mg 25 mg 25 mg 50 mg 50 mg 5 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
Smiles	NC1=C2C(=NN(C2=NC=N1)C3CCNCC3)C4=CC=C(OC5=CC=CC=C5)C=C4
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Shipping Condition	Cool pack
Available
Manufacturer - Targets	Ligands for Target Protein for PROTAC\|\|\|BTK
Shipping Temperature	Cool pack
Storage Conditions	-20°C
Molecular Weight	386, 45
Description	N-piperidine Ibrutinib is a potent BTK inhibitor with IC50s of 51.0 for WT BTK and 30.7 nM for C481S BTK respectively. N-piperidine Ibrutinib can be used as a BTK ligand in the synthesis of a series of PROTACs, such as SJF620. SJF620 is a potent PROTAC BTK degrader with a DC50 of 7.9 nM.
Pathways	Angiogenesis\|\|\|PROTAC\|\|\|Tyrosine Kinase/Adaptors

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 5 mg

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