[KO Validated] HDAC1 Rabbit pAb (APR17360N)

pAbs-N

Calculated MW: 55kDaObserved MW: 62kDa

Recombinant fusion protein containing a sequence corresponding to amino acids 393-482 of human HDAC1 (NP_004955.2).

Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis.

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH 7.3.

Affinity purification