Anti-Mouse CD3ε (Clone 145-2C11) F(ab')2 fragment – Purified in vivo GOLD™ Functional Grade - 25 mg

Depletion, in vivo

Next Day 2 - 8°C

Derived from the 145-2C11 monoclonal antibody, this product provides the F(ab’)2 fragment, targeting the 20 kDa transmembrane CD3ε protein, a crucial component of the TCR complex on T lymphocytes, NK-T cells, and thymocytes. Pepsin digestion removes the Fc region, ensuring minimal non-specific binding and preventing Fcγ receptor-mediated cross-linking. This F(ab’)2 fragment is designed for in vivo applications where the full 145-2C11 antibody's T cell activation can lead to adverse effects. It induces apoptosis in antigen-activated T cells by promoting sustained TCR expression and signaling, while Foxp3+ regulatory T cells remain unaffected.

≥ 5.0 mg/ml

CD3ε is primarily expressed on mature T cells and NK-T cells and at different levels on differentiation-dependent thymocytes.