Anti-Mouse CD31 (PECAM-1) - Purified <i>in vivo</i> PLATINUM™ Functional Grade - 5 mg

B, ELISA, FA, FC, IF, IHC, IP, LCI, RIA

2 - 8°C Wet Ice

PECAM-1 was the first immunoreceptor tyrosine-based inhibition motif (ITIM)-containingreceptor to be identified in platelets and acts as a negative regulator of platelet activation1.Platelet activation from a resting state has broad implications for many pathophysiologicalprocesses including anthogenesis, angiogenesis, inflammation, wound repair, and cancermetastasis. PECAM-1 inhibits platelet activation and thrombosis at sites of vascular injury byattenuating immunoreceptor tyrosine-based activation motif (ITAM)-containing receptorcomplex GPVI-FcR γ-chain signaling and by acting as a positive regulator of αIIbβ3-mediatedoutside-in signaling. PECAM-1, like all ITIM-containing receptors, belongs to theimmunoglobulin receptor superfamily. PECAM-1 also functions as a cell adhesion molecule and is capable of mediating calcium-dependent heterophilic aggregation2. Additionally, PECAM-1 is expressed at cell-cell borders inthe endocardial cells of the developing murine heart3. Because of its distribution pattern, PECAM-1 is a target molecule for the delivery of antithrombotic agents4, 5, 6, 7. Research is beingconducted into the ability of PECAM-1 to deliver drugs to the endothelium. Clone 390 was generated by immunizing rats with mouse 32D leukocyte cell line and screeningagainst muPECAM-1Δ12, 153, 8. 390 binds to an epitope on Ig-domain 2 of muPECAM-17, 9.

≥ 5.0 mg/ml

PECAM-1 is expressed on the majority of non-erythroid hematopoieticcells, including platelets, monocytes, neutrophils, T cells, and B cell subsets, as well as onvascular endothelium and the endocardial cells of developing heart tissue.