Anti-Mouse CD18 [Clone M18/2] — Purified in vivo GOLD™ Functional Grade - 100 mg

Primary Monoclonal Antibodies

2 - 8 °C Wet Ice

Integrins are a large family of α/β heterodimeric transmembrane molecules that mediate
adhesion, migration, cell survival, and cell differentiation1. The leukocytic cell-adhesion
molecule (Leu-CAM) family has three members, LFA-1 (CD18/CD11a), CR3 (also known as
MAC-1) (CD18/CD11b), and p150, 95 (CD18/CD11c), all of which share the β chain CD182.
Depending on which molecule CD18 is bound to, this β chain plays important roles in
inflammation, initiation of the immune response, phagocytosis, adherence to endothelium,
chemotaxis, and can act as a fibrinogen receptor as part of its heterodimer3.

M18/2 was generated by immunizing rat with mouse cytotoxic T cell glycoproteins and fusing
the spleen cells with mouse myeloma line P3X63Ag8.6534. M18/2 was selected by
immunoprecipitation of LFA-1 and found to bind to the β chain of both LFA-1 and MAC-1.
M18/2 has subsequently been used to study lymphoma metastasis3, 5, myelin phagocytosis6,
platelet caspases and thrombocytosis7, and the immunosuppression of corneal allografts8.

≥ 5.0 mg/ml

CD18 is expressed on all leukocytes as well as on myeloid cells.