Comparison

Anti-Human ICAM-1 (CD54) (Clone R6-5-D6) - Recombinant <i>in vivo</i> Functional Grade - 5 mg

Item no. LEIN-C877-5mg
Manufacturer Leinco Technologies
Amount 5 mg
Quantity options 1 mg 5 mg
Category
Type Antibody Monoclonal, recombinant
Applications FC, IF, FA
Clone R6-5-D6
Specific against other
ECLASS 10.1 42030590
ECLASS 11.0 42030590
UNSPSC 12352203
Shipping Condition Cool pack
Available
Manufacturer - Category
All|Primary Monoclonal Antibodies
Manufacturer - Targets
CD54, ICAM-1
Shipping Temperature
2 - 8°C Wet Ice
Storage Conditions
Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at ≤ -70°C. Avoid Repeated Freeze Thaw Cycles.
Product Description
ICAM-1 or CD54 is a glycoprotein found on the surface of endothelial and epithelial cells duringinflammation. It plays a significant role in the interactions between cells and immune responses. ICAM-1helps in the adhesion and movement of leukocytes expressing activated LFA-1 (CD11a/CD18) and Mac-1(CD11b/CD18)1. Studies suggest that sICAM-1 (soluble ICAM-1) can bind to various non-integrin ligands, such asCD43/sialophorin, fibrinogen, hyaluronan, rhinoviruses, and Plasmodium falciparum-infectederythrocytes. In addition, sICAM-1 can be used as an indicator of vascular endothelial cell activation ordamage by promoting angiogenesis2. Increased levels of sICAM-1 are associated with various diseases such as chronic coronary heart disease, type 2 diabetes, organ transplant dysfunction, oxidant stress, and certain malignancies3-5. Clone R6-5-D6, is a monoclonal antibody that has been used in research to study the expression andfunction of ICAM-1 in different contexts, such as viral infections, solid tumors, and graft-versus-hostdisease. The antibody has shown efficacy in inhibiting infection, characterizing ICAM-1 expression, andenhancing immune responses6-9. It also inhibits CD54 interaction with leukocytes, thereby reducinginflammation10, 11.
Manufacturer - Research Area
Costimulatory Molecules, Immunology, Neuroscience
Concentration
≥ 5.0 mg/ml
Formulation
This recombinant monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.
Antigen Distribution
CD54 is typically expressed on non-hematopoietic cells such as endothelial cells, thymic epithelial cells, fibroblasts, macrophages, T-lymphoblasts, germinal center B cells and dendriticcells.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 5 mg
Available: In stock
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