Anti-Human CD28 (Clone 9.3) - Biotin - 100 µg

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2 - 8°C Wet Ice

CD28, a glycoprotein weighing 44 kDa is a member of the Ig superfamily and plays a vital role, in theactivation and survival of T cells1, 2 by enhancing the production of interleukin and the activity of T cells.CD28 is unique among B7 receptors as it is consistently expressed on T cells. The interaction betweenCD28 and B7 is crucial for preventing T cells from becoming anergic and unable to respond toantigen/MHC complexes highlighting its role in an immune response3-6.The clone 9.3 has gained recognition for its ability to stimulate the growth of human T cells in vitromaking it a valuable tool for research focused on studying T cell activation and immune responses. Itwas developed by immunizing mice with human T cells. It has demonstrated effectiveness in inducing Tcell activation and proliferation when combined with TPA thereby influencing IL 2 receptor expressionand IL 2 production7. This clone can be utilized for staining a portion of T cells throughimmunofluorescence methods and has proven successful in immunoprecipitating CD28 from Jurkat cells8. Given its ability to activate T cells and its reactivity with CD28, the 9.3 clone stands as a resource forresearch.

0.5 mg/ml

CD28 is primarily expressed by thymocytes, most peripheral T cells, and naturalkiller (NK) cells.